abstract：:The uranyl ion (UO22+; U(VI) oxidation state) is the most common form of uranium found in terrestrial and aquatic environments and is a central component in nuclear fuel processing and waste remediation efforts. Uranyl capture from either seawater or nuclear waste has been well studied and typically relies on extremel...

journal_title：Nature

authors： Keener M,Hunt C,Carroll TG,Kampel V,Dobrovetsky R,Hayton TW,Ménard G

更新日期：2020-01-01 00:00:00

abstract：:Activation of RIPK1 controls TNF-mediated apoptosis, necroptosis and inflammatory pathways1. Cleavage of human and mouse RIPK1 after residues D324 and D325, respectively, by caspase-8 separates the RIPK1 kinase domain from the intermediate and death domains. The D325A mutation in mouse RIPK1 leads to embryonic lethali...

journal_title：Nature

authors： Tao P,Sun J,Wu Z,Wang S,Wang J,Li W,Pan H,Bai R,Zhang J,Wang Y,Lee PY,Ying W,Zhou Q,Hou J,Wang W,Sun B,Yang M,Liu D,Fang R,Han H,Yang Z,Huang X,Li H,Deuitch N,Zhang Y,Dissanayake D,Haude K,McWalter K

更新日期：2020-01-01 00:00:00

abstract：:Humoral immune responses to immunization and infection and susceptibilities to antibody-mediated autoimmunity are generally lower in males1-3. However, the mechanisms underlying such sexual dimorphism are not well understood. Here we show that there are intrinsic differences between the B cells that produce germinal c...

journal_title：Nature

authors： Zhao R,Chen X,Ma W,Zhang J,Guo J,Zhong X,Yao J,Sun J,Rubinfien J,Zhou X,Wang J,Qi H

更新日期：2020-01-01 00:00:00

abstract：:Mycobacterium tuberculosis (Mtb) is the leading cause of death from infection worldwide1. The only available vaccine, BCG (Bacillus Calmette-Guérin), is given intradermally and has variable efficacy against pulmonary tuberculosis, the major cause of mortality and disease transmission1,2. Here we show that intravenous ...

journal_title：Nature

authors： Darrah PA,Zeppa JJ,Maiello P,Hackney JA,Wadsworth MH 2nd,Hughes TK,Pokkali S,Swanson PA 2nd,Grant NL,Rodgers MA,Kamath M,Causgrove CM,Laddy DJ,Bonavia A,Casimiro D,Lin PL,Klein E,White AG,Scanga CA,Shalek AK,Roede

更新日期：2020-01-01 00:00:00

abstract：:Highly efficient neutron detectors are critical in many sectors, including national security1,2, medicine3, crystallography4 and astronomy5. The main neutron detection technologies currently used involve 3He-gas-filled proportional counters6 and light scintillators7 for thermalized neutrons. Semiconductors could provi...

journal_title：Nature

authors： Chica DG,He Y,McCall KM,Chung DY,Pak RO,Trimarchi G,Liu Z,De Lurgio PM,Wessels BW,Kanatzidis MG

更新日期：2020-01-01 00:00:00

abstract：:The hippocampus is an important part of the limbic system in the human brain that has essential roles in spatial navigation and the consolidation of information from short-term memory to long-term memory1,2. Here we use single-cell RNA sequencing and assay for transposase-accessible chromatin using sequencing (ATAC-se...

journal_title：Nature

authors： Zhong S,Ding W,Sun L,Lu Y,Dong H,Fan X,Liu Z,Chen R,Zhang S,Ma Q,Tang F,Wu Q,Wang X

更新日期：2020-01-01 00:00:00

abstract：:An Amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature

authors： Momcilovic M,Jones A,Bailey ST,Waldmann CM,Li R,Lee JT,Abdelhady G,Gomez A,Holloway T,Schmid E,Stout D,Fishbein MC,Stiles L,Dabir DV,Dubinett SM,Christofk H,Shirihai O,Koehler CM,Sadeghi S,Shackelford DB

更新日期：2020-01-01 00:00:00

abstract：:Mammals form scars to quickly seal wounds and ensure survival by an incompletely understood mechanism1-5. Here we show that skin scars originate from prefabricated matrix in the subcutaneous fascia. Fate mapping and live imaging revealed that fascia fibroblasts rise to the skin surface after wounding, dragging their s...

journal_title：Nature

authors： Correa-Gallegos D,Jiang D,Christ S,Ramesh P,Ye H,Wannemacher J,Kalgudde Gopal S,Yu Q,Aichler M,Walch A,Mirastschijski U,Volz T,Rinkevich Y

更新日期：2019-12-01 00:00:00

abstract：:The current need for novel antibiotics is especially acute for drug-resistant Gram-negative pathogens1,2. These microorganisms have a highly restrictive permeability barrier, which limits the penetration of most compounds3,4. As a result, the last class of antibiotics that acted against Gram-negative bacteria was deve...

journal_title：Nature

authors： Imai Y,Meyer KJ,Iinishi A,Favre-Godal Q,Green R,Manuse S,Caboni M,Mori M,Niles S,Ghiglieri M,Honrao C,Ma X,Guo JJ,Makriyannis A,Linares-Otoya L,Böhringer N,Wuisan ZG,Kaur H,Wu R,Mateus A,Typas A,Savitski MM,Es

更新日期：2019-12-01 00:00:00

abstract：:Many animals rely on an internal heading representation when navigating in varied environments1-10. How this representation is linked to the sensory cues that define different surroundings is unclear. In the fly brain, heading is represented by 'compass' neurons that innervate a ring-shaped structure known as the elli...

journal_title：Nature

authors： Kim SS,Hermundstad AM,Romani S,Abbott LF,Jayaraman V

更新日期：2019-12-01 00:00:00

abstract：:Despite considerable global investment, only 60% of people who live with HIV currently receive antiretroviral therapy. The sustainability of current programmes remains unknown and key incidence rates are declining only modestly. Given the complexities and expenses associated with lifelong medication, developing an eff...

journal_title：Nature

authors： Ndung'u T,McCune JM,Deeks SG

更新日期：2019-12-01 00:00:00

abstract：:Among the ten subtypes of mammalian voltage-gated calcium (Cav) channels, Cav3.1-Cav3.3 constitute the T-type, or the low-voltage-activated, subfamily, the abnormal activities of which are associated with epilepsy, psychiatric disorders and pain1-5. Here we report the cryo-electron microscopy structures of human Cav3....

journal_title：Nature

authors： Zhao Y,Huang G,Wu Q,Wu K,Li R,Lei J,Pan X,Yan N

更新日期：2019-12-01 00:00:00

abstract：:Gigantopithecus blacki was a giant hominid that inhabited densely forested environments of Southeast Asia during the Pleistocene epoch1. Its evolutionary relationships to other great ape species, and the divergence of these species during the Middle and Late Miocene epoch (16-5.3 million years ago), remain unclear2,3....

journal_title：Nature

authors： Welker F,Ramos-Madrigal J,Kuhlwilm M,Liao W,Gutenbrunner P,de Manuel M,Samodova D,Mackie M,Allentoft ME,Bacon AM,Collins MJ,Cox J,Lalueza-Fox C,Olsen JV,Demeter F,Wang W,Marques-Bonet T,Cappellini E

更新日期：2019-12-01 00:00:00

abstract：:Limiting the increase of CO2 in the atmosphere is one of the largest challenges of our generation1. Because carbon capture and storage is one of the few viable technologies that can mitigate current CO2 emissions2, much effort is focused on developing solid adsorbents that can efficiently capture CO2 from flue gases e...

journal_title：Nature

authors： Boyd PG,Chidambaram A,García-Díez E,Ireland CP,Daff TD,Bounds R,Gładysiak A,Schouwink P,Moosavi SM,Maroto-Valer MM,Reimer JA,Navarro JAR,Woo TK,Garcia S,Stylianou KC,Smit B

更新日期：2019-12-01 00:00:00

abstract：:Embryonal tumours with multilayered rosettes (ETMRs) are aggressive paediatric embryonal brain tumours with a universally poor prognosis1. Here we collected 193 primary ETMRs and 23 matched relapse samples to investigate the genomic landscape of this distinct tumour type. We found that patients with tumours in which t...

journal_title：Nature

authors： Lambo S,Gröbner SN,Rausch T,Waszak SM,Schmidt C,Gorthi A,Romero JC,Mauermann M,Brabetz S,Krausert S,Buchhalter I,Koster J,Zwijnenburg DA,Sill M,Hübner JM,Mack N,Schwalm B,Ryzhova M,Hovestadt V,Papillon-Cavanagh S,

更新日期：2019-12-01 00:00:00

abstract：:Guided by brain-like 'spiking' computational frameworks, neuromorphic computing-brain-inspired computing for machine intelligence-promises to realize artificial intelligence while reducing the energy requirements of computing platforms. This interdisciplinary field began with the implementation of silicon circuits for...

journal_title：Nature

authors： Roy K,Jaiswal A,Panda P

更新日期：2019-11-01 00:00:00

abstract：:Supramolecular soft crystals are periodic structures that are formed by the hierarchical assembly of complex constituents, and occur in a broad variety of 'soft-matter' systems1. Such soft crystals exhibit many of the basic features (such as three-dimensional lattices and space groups) and properties (such as band str...

journal_title：Nature

authors： Feng X,Burke CJ,Zhuo M,Guo H,Yang K,Reddy A,Prasad I,Ho RM,Avgeropoulos A,Grason GM,Thomas EL

更新日期：2019-11-01 00:00:00

abstract：:Ferroptosis is a form of regulated cell death that is caused by the iron-dependent peroxidation of lipids1,2. The glutathione-dependent lipid hydroperoxidase glutathione peroxidase 4 (GPX4) prevents ferroptosis by converting lipid hydroperoxides into non-toxic lipid alcohols3,4. Ferroptosis has previously been implica...

journal_title：Nature

authors： Bersuker K,Hendricks JM,Li Z,Magtanong L,Ford B,Tang PH,Roberts MA,Tong B,Maimone TJ,Zoncu R,Bassik MC,Nomura DK,Dixon SJ,Olzmann JA

更新日期：2019-11-01 00:00:00

abstract：:Astrophysical observations indicate that there is roughly five times more dark matter in the Universe than ordinary baryonic matter1, and an even larger amount of the Universe's energy content is attributed to dark energy2. However, the microscopic properties of these dark components remain unknown. Moreover, even ord...

journal_title：Nature

authors： Smorra C,Stadnik YV,Blessing PE,Bohman M,Borchert MJ,Devlin JA,Erlewein S,Harrington JA,Higuchi T,Mooser A,Schneider G,Wiesinger M,Wursten E,Blaum K,Matsuda Y,Ospelkaus C,Quint W,Walz J,Yamazaki Y,Budker D,Ulmer S

更新日期：2019-11-01 00:00:00

abstract：:Methane is a powerful greenhouse gas and is targeted for emissions mitigation by the US state of California and other jurisdictions worldwide1,2. Unique opportunities for mitigation are presented by point-source emitters-surface features or infrastructure components that are typically less than 10 metres in diameter a...

journal_title：Nature

authors： Duren RM,Thorpe AK,Foster KT,Rafiq T,Hopkins FM,Yadav V,Bue BD,Thompson DR,Conley S,Colombi NK,Frankenberg C,McCubbin IB,Eastwood ML,Falk M,Herner JD,Croes BE,Green RO,Miller CE

更新日期：2019-11-01 00:00:00

abstract：:The Fanconi anaemia (FA) pathway repairs DNA damage caused by endogenous and chemotherapy-induced DNA crosslinks, and responds to replication stress1,2. Genetic inactivation of this pathway by mutation of genes encoding FA complementation group (FANC) proteins impairs development, prevents blood production and promote...

journal_title：Nature

authors： Shakeel S,Rajendra E,Alcón P,O'Reilly F,Chorev DS,Maslen S,Degliesposti G,Russo CJ,He S,Hill CH,Skehel JM,Scheres SHW,Patel KJ,Rappsilber J,Robinson CV,Passmore LA

更新日期：2019-11-01 00:00:00

abstract：:Liver cirrhosis is a major cause of death worldwide and is characterized by extensive fibrosis. There are currently no effective antifibrotic therapies available. To obtain a better understanding of the cellular and molecular mechanisms involved in disease pathogenesis and enable the discovery of therapeutic targets, ...

journal_title：Nature

authors： Ramachandran P,Dobie R,Wilson-Kanamori JR,Dora EF,Henderson BEP,Luu NT,Portman JR,Matchett KP,Brice M,Marwick JA,Taylor RS,Efremova M,Vento-Tormo R,Carragher NO,Kendall TJ,Fallowfield JA,Harrison EM,Mole DJ,Wigmore SJ

更新日期：2019-11-01 00:00:00

abstract：:Multicellular organisms have co-evolved with complex consortia of viruses, bacteria, fungi and parasites, collectively referred to as the microbiota1. In mammals, changes in the composition of the microbiota can influence many physiologic processes (including development, metabolism and immune cell function) and are a...

journal_title：Nature

authors： Chu C,Murdock MH,Jing D,Won TH,Chung H,Kressel AM,Tsaava T,Addorisio ME,Putzel GG,Zhou L,Bessman NJ,Yang R,Moriyama S,Parkhurst CN,Li A,Meyer HC,Teng F,Chavan SS,Tracey KJ,Regev A,Schroeder FC,Lee FS,Liston C

更新日期：2019-10-01 00:00:00

abstract：:The colorectal adenoma-carcinoma sequence has provided a paradigmatic framework for understanding the successive somatic genetic changes and consequent clonal expansions that lead to cancer1. However, our understanding of the earliest phases of colorectal neoplastic changes-which may occur in morphologically normal ti...

journal_title：Nature

authors： Lee-Six H,Olafsson S,Ellis P,Osborne RJ,Sanders MA,Moore L,Georgakopoulos N,Torrente F,Noorani A,Goddard M,Robinson P,Coorens THH,O'Neill L,Alder C,Wang J,Fitzgerald RC,Zilbauer M,Coleman N,Saeb-Parsy K,Martincorena

更新日期：2019-10-01 00:00:00

abstract：:The ability of the immune system to eliminate and shape the immunogenicity of tumours defines the process of cancer immunoediting1. Immunotherapies such as those that target immune checkpoint molecules can be used to augment immune-mediated elimination of tumours and have resulted in durable responses in patients with...

journal_title：Nature

authors： Alspach E,Lussier DM,Miceli AP,Kizhvatov I,DuPage M,Luoma AM,Meng W,Lichti CF,Esaulova E,Vomund AN,Runci D,Ward JP,Gubin MM,Medrano RFV,Arthur CD,White JM,Sheehan KCF,Chen A,Wucherpfennig KW,Jacks T,Unanue ER,Ar

更新日期：2019-10-01 00:00:00

abstract：:The sequencing of ancient DNA has enabled the reconstruction of speciation, migration and admixture events for extinct taxa1. However, the irreversible post-mortem degradation2 of ancient DNA has so far limited its recovery-outside permafrost areas-to specimens that are not older than approximately 0.5 million years (...

journal_title：Nature

authors： Cappellini E,Welker F,Pandolfi L,Ramos-Madrigal J,Samodova D,Rüther PL,Fotakis AK,Lyon D,Moreno-Mayar JV,Bukhsianidze M,Rakownikow Jersie-Christensen R,Mackie M,Ginolhac A,Ferring R,Tappen M,Palkopoulou E,Dickinson MR,S

更新日期：2019-10-01 00:00:00

abstract：:Protoplanetary disks are known to possess a variety of substructures in the distribution of their millimetre-sized grains, predominantly seen as rings and gaps1, which are frequently interpreted as arising from the shepherding of large grains by either hidden, still-forming planets within the disk2 or (magneto-)hydrod...

journal_title：Nature

authors： Teague R,Bae J,Bergin EA

更新日期：2019-10-01 00:00:00

abstract：:In eukaryotes, accurate chromosome segregation in mitosis and meiosis maintains genome stability and prevents aneuploidy. Kinetochores are large protein complexes that, by assembling onto specialized Cenp-A nucleosomes1,2, function to connect centromeric chromatin to microtubules of the mitotic spindle3,4. Whereas the...

journal_title：Nature

authors： Yan K,Yang J,Zhang Z,McLaughlin SH,Chang L,Fasci D,Ehrenhofer-Murray AE,Heck AJR,Barford D

更新日期：2019-10-01 00:00:00

abstract：:Supersolids are exotic materials combining the frictionless flow of a superfluid with the crystal-like periodic density modulation of a solid. The supersolid phase of matter was predicted 50 years ago1-3 for solid helium4-8. Ultracold quantum gases have recently been made to exhibit periodic order typical of a crystal...

journal_title：Nature

authors： Tanzi L,Roccuzzo SM,Lucioni E,Famà F,Fioretti A,Gabbanini C,Modugno G,Recati A,Stringari S

更新日期：2019-10-01 00:00:00

abstract：:Over the past eight hundred thousand years, glacial-interglacial cycles oscillated with a period of one hundred thousand years ('100k world'1). Ice core and ocean sediment data have shown that atmospheric carbon dioxide, Antarctic temperature, deep ocean temperature, and global ice volume correlated strongly with each...

journal_title：Nature

authors： Yan Y,Bender ML,Brook EJ,Clifford HM,Kemeny PC,Kurbatov AV,Mackay S,Mayewski PA,Ng J,Severinghaus JP,Higgins JA

更新日期：2019-10-01 00:00:00

abstract：:Transition-metal complexes are widely used in the physical and biological sciences. They have essential roles in catalysis, synthesis, materials science, photophysics and bioinorganic chemistry. Our understanding of transition-metal complexes originates from Alfred Werner's realization that their three-dimensional sha...

journal_title：Nature

authors： Garçon M,Bakewell C,Sackman GA,White AJP,Cooper RI,Edwards AJ,Crimmin MR

更新日期：2019-10-01 00:00:00

abstract：:B cells are important in the pathogenesis of many, and perhaps all, immune-mediated diseases. Each B cell expresses a single B cell receptor (BCR)1, and the diverse range of BCRs expressed by the total B cell population of an individual is termed the 'BCR repertoire'. Our understanding of the BCR repertoire in the con...

journal_title：Nature

authors： Bashford-Rogers RJM,Bergamaschi L,McKinney EF,Pombal DC,Mescia F,Lee JC,Thomas DC,Flint SM,Kellam P,Jayne DRW,Lyons PA,Smith KGC

更新日期：2019-10-01 00:00:00

abstract：:The cranial morphology of the earliest known hominins in the genus Australopithecus remains unclear. The oldest species in this genus (Australopithecus anamensis, specimens of which have been dated to 4.2-3.9 million years ago) is known primarily from jaws and teeth, whereas younger species (dated to 3.5-2.0 million y...

journal_title：Nature

authors： Haile-Selassie Y,Melillo SM,Vazzana A,Benazzi S,Ryan TM

更新日期：2019-09-01 00:00:00

abstract：:An Amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature

authors： Segel M,Neumann B,Hill MFE,Weber IP,Viscomi C,Zhao C,Young A,Agley CC,Thompson AJ,Gonzalez GA,Sharma A,Holmqvist S,Rowitch DH,Franze K,Franklin RJM,Chalut KJ

更新日期：2019-09-01 00:00:00

abstract：:The molecular mechanisms of exon definition and back-splicing are fundamental unanswered questions in pre-mRNA splicing. Here we report cryo-electron microscopy structures of the yeast spliceosomal E complex assembled on introns, providing a view of the earliest event in the splicing cycle that commits pre-mRNAs to sp...

journal_title：Nature

authors： Li X,Liu S,Zhang L,Issaian A,Hill RC,Espinosa S,Shi S,Cui Y,Kappel K,Das R,Hansen KC,Zhou ZH,Zhao R

更新日期：2019-09-01 00:00:00

abstract：:Translation initiation determines both the quantity and identity of the protein that is encoded in an mRNA by establishing the reading frame for protein synthesis. In eukaryotic cells, numerous translation initiation factors prepare ribosomes for polypeptide synthesis; however, the underlying dynamics of this process ...

journal_title：Nature

authors： Wang J,Johnson AG,Lapointe CP,Choi J,Prabhakar A,Chen DH,Petrov AN,Puglisi JD

更新日期：2019-09-01 00:00:00

abstract：:Online hate and extremist narratives have been linked to abhorrent real-world events, including a current surge in hate crimes1-6 and an alarming increase in youth suicides that result from social media vitriol7; inciting mass shootings such as the 2019 attack in Christchurch, stabbings and bombings8-11; recruitment o...

journal_title：Nature

authors： Johnson NF,Leahy R,Restrepo NJ,Velasquez N,Zheng M,Manrique P,Devkota P,Wuchty S

更新日期：2019-09-01 00:00:00

abstract：:Organic photovoltaic cells are now approaching commercially viable efficiencies, particularly for applications that make use of their unique potential for flexibility and semitransparency1-3. However, their reliability remains a major concern, as even the most stable devices reported so far degrade within only a few y...

journal_title：Nature

authors： Burlingame Q,Huang X,Liu X,Jeong C,Coburn C,Forrest SR

更新日期：2019-09-01 00:00:00

abstract：:High-pressure transitions are thought to modify hydrogen molecules to a molecular metallic solid and finally to an atomic metal1, which is predicted to have exotic physical properties and the topology of a two-component (electron and proton) superconducting superfluid condensate2,3. Therefore, understanding such trans...

journal_title：Nature

authors： Ji C,Li B,Liu W,Smith JS,Majumdar A,Luo W,Ahuja R,Shu J,Wang J,Sinogeikin S,Meng Y,Prakapenka VB,Greenberg E,Xu R,Huang X,Yang W,Shen G,Mao WL,Mao HK

更新日期：2019-09-01 00:00:00

abstract：:The electronic properties of heterostructures of atomically thin van der Waals crystals can be modified substantially by moiré superlattice potentials from an interlayer twist between crystals1,2. Moiré tuning of the band structure has led to the recent discovery of superconductivity3,4 and correlated insulating phase...

journal_title：Nature

authors： Kerelsky A,McGilly LJ,Kennes DM,Xian L,Yankowitz M,Chen S,Watanabe K,Taniguchi T,Hone J,Dean C,Rubio A,Pasupathy AN

更新日期：2019-08-01 00:00:00